کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050732 1074180 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells
چکیده انگلیسی

Elongation of very long-chain fatty acids (ELOVL) members were overexpressed in two preadipocyte cell lines, ELOVL2 and ELOVL3 in 3T3-L1 cells, and ELOVL1–3 in F442A cells. Cells overexpressing ELOVL2, whose preferred substrates are arachidonic acid (AA, C20:4n−6) and eicosapentaenoic acid (EPA, C20:5n−3), showed an enhanced triacylglycerol (TAG) synthesis and subsequent accumulation of lipid droplets. Incorporation of fatty acid (FA) but not of glucose into TAG was enhanced by ELOVL2-overexpression. Two lipogenic genes encoding diacylglycerol acyltransferase-2 (DGAT2) and fatty acid-binding protein-4 (FABP4, aP2) were induced in ELOVL2-overexpressing cells, whereas no such effect was seen on the fatty acid synthase (FAS) gene.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 17, 10 July 2007, Pages 3157–3163
نویسندگان
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