کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050774 | 1074181 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice](/preview/png/2050774.png)
چکیده انگلیسی
Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABAB agonists could be a new therapeutic reagent for obesity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 25, 16 October 2007, Pages 4857–4864
Journal: FEBS Letters - Volume 581, Issue 25, 16 October 2007, Pages 4857–4864
نویسندگان
Ikuko Sato, Hiroshi Arima, Noriyuki Ozaki, Nobuaki Ozaki, Minemori Watanabe, Motomitsu Goto, Hiroshi Shimizu, Masayuki Hayashi, Ryouichi Banno, Hiroshi Nagasaki, Yutaka Oiso,