کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050867 | 1074183 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prediction of replication time zones at single nucleotide resolution in the human genome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Prediction of replication time zones at single nucleotide resolution in the human genome Prediction of replication time zones at single nucleotide resolution in the human genome](/preview/png/2050867.png)
چکیده انگلیسی
The human genome is structured at multiple levels: it is organized into a series of replication time zones, and meanwhile it is composed of isochores. Accumulating evidence suggests a match between these two genome features. Based on newly developed software GC-Profile, we obtained a complete coverage of the human genome by 3198 isochores with boundaries at single nucleotide resolution. Interestingly, the experimentally confirmed replication timing sites in the regions of 1p36.1, 6p21.32, 17q11.2 and 22q12.1 nearly all coincide with the determined isochore boundaries. The precise boundaries of the 3198 isochores are available via the website: http://tubic.tju.edu.cn/isomap/.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 16, 9 July 2008, Pages 2441–2444
Journal: FEBS Letters - Volume 582, Issue 16, 9 July 2008, Pages 2441–2444
نویسندگان
Feng Gao, Chun-Ting Zhang,