کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050879 1074184 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Muscle atrophy in transgenic mice expressing a human TSC1 transgene
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Muscle atrophy in transgenic mice expressing a human TSC1 transgene
چکیده انگلیسی

Muscle mass is regulated by a wide range of hormonal and nutritional signals, such as insulin and IGF. Tuberous sclerosis complex (TSC) is an inherited hamartoma disease with tumor growth in numerous organs. TSC is caused by mutation in either TSC1 or TSC2 tumor suppressor genes that negatively regulate insulin-induced S6K activation and cell growth. Here we report that expression of human TSC1 (hTSC1) in mouse skeletal muscle leads to reduction of muscle mass. Expression of hTSC1 stabilizes endogenous TSC2 and leads to inhibition of the mTOR signaling. The hTSC1-mTSC2 hetero-complex and its downstream components remain sensitive to insulin stimulation and nutrition signals. This study suggests that an increase in the steady state level of resident TSC1–TSC2 complex is sufficient to reduce muscle mass and cause atrophy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 24, 16 October 2006, Pages 5621–5627
نویسندگان
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