کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050885 | 1074184 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bimodal actions of reactive oxygen species in the differentiation and bone-resorbing functions of osteoclasts
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Bimodal actions of reactive oxygen species in the differentiation and bone-resorbing functions of osteoclasts Bimodal actions of reactive oxygen species in the differentiation and bone-resorbing functions of osteoclasts](/preview/png/2050885.png)
چکیده انگلیسی
In order to demonstrate that cellular redox status undergoes decreased reduction during osteoclast differentiation and further decreased reduction during osteoclastic bone resorption, we analyzed γ-glutamylcysteinyl synthetase activity, a glutathione synthesis rate-limiting enzyme, and total glutathione and thiol groups. Moderate and severe redox shifts towards a more oxidizing environment induced gradual increases and decreases in osteoclastogenesis. Moreover, while severe glutathione depletion inhibited bone resorption, moderate glutathione repletion enhanced bone resorption. In summary, our observations suggest that there is a threshold for redox status, representing biphasic patterns in osteoclast differentiation and function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 24, 16 October 2006, Pages 5661–5665
Journal: FEBS Letters - Volume 580, Issue 24, 16 October 2006, Pages 5661–5665
نویسندگان
Hyunsoo Kim, Ick Young Kim, Soo Young Lee, Daewon Jeong,