کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050896 | 1074184 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels](/preview/png/2050896.png)
چکیده انگلیسی
Cnidarian envenomations cause a burning-pain sensation of which the underlying mechanisms are unknown. Activation of TRPV1, a non-selective cation channel expressed in nociceptive neurons, leads to cell depolarisation and pain. Here, we show in vitro and in vivo evidence for desensitization-dependent TRPV1 activation in cnidarian envenomations. Cnidarian venom induced a nociceptive reactivity, comparable to capsaicin, in laboratory rats, which could be reduced by the selective TRPV1 antagonist, BCTC. These findings are the first to explain at least part of the symptomology of cnidarian envenomations and provide insights into the design of more effective treatments for this global public health problem.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 24, 16 October 2006, Pages 5728–5732
Journal: FEBS Letters - Volume 580, Issue 24, 16 October 2006, Pages 5728–5732
نویسندگان
Eva Cuypers, Angel Yanagihara, Evert Karlsson, Jan Tytgat,