کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051029 1074189 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Moderate overexpression of AIB1 triggers pre-neoplastic changes in mammary epithelium
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Moderate overexpression of AIB1 triggers pre-neoplastic changes in mammary epithelium
چکیده انگلیسی

Here we report a new model of pre-clinical breast cancer which has been generated by overexpressing the steroid receptor coactivator AIB1 at moderate levels in breast epithelium. Transgenic female mice display mammary hyperplasia at the onset of puberty, consistent with enhanced proliferation of primary mammary epithelial cultures and augmented levels of cyclin D1 and E-cadherin. Studies of BrdU incorporation revealed that AIB1 localizes to the nucleus during or after S phase, implicating a new role for AIB1 in cell-cycle progression subsequent to G1. Our findings suggest that moderate overexpression of AIB1 may represent one of the pre-neoplastic changes in breast tissue.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 22, 2 October 2006, Pages 5222–5226
نویسندگان
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