کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051037 1074189 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Topological accessibility shows a distinct asymmetry in the folds of βα proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Topological accessibility shows a distinct asymmetry in the folds of βα proteins
چکیده انگلیسی

A novel measure, called “topological accessibility” quantifies how easy it is to reconstruct a protein structure using only local contacts when starting at any point on the chain. Plotting this measure for all points in the chain gives a picture of how accessible the fold is. Simple folds are accessible from all positions, others are accessible only from limited positions while the most complex folds are not accessible from any position. The distribution of topological accessibility along the chain was found to be completely symmetric for the all-α and all-β protein classes. However, for the βα class, a distinct asymmetry was found (with probability 10−30 of being due to chance). Examination of the proteins contributing to this signal indicated many that have an ancient origin. This suggests that the folds of these proteins may have become fixed under the influence of amino-terminal folding before the advent of chaperone assisted folding.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 22, 2 October 2006, Pages 5263–5267
نویسندگان
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