کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051147 | 1074193 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum amyloid A-induced IL-6 production by rheumatoid synoviocytes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Serum amyloid A-induced IL-6 production by rheumatoid synoviocytes Serum amyloid A-induced IL-6 production by rheumatoid synoviocytes](/preview/png/2051147.png)
چکیده انگلیسی
In this study, we investigated the role of serum amyloid A protein (SAA) in the production of interleukin-6 (IL-6) using rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Recombinant SAA stimulation induced the production of pro-inflammatory cytokine, IL-6, from RA-FLS. The signaling events induced by SAA included the activation of the mitogen-activated protein kineases, p38 and JNK1/2 and the activation of nuclear factor-kappa B (NF-κB). Inhibitor studies have shown SAA-induced IL-6 production to be down-regulated by NF-κB inhibition and partially inhibited by p38 or JNK inhibitors. Our findings demonstrate that SAA is a significant inducer of IL-6, which is critically involved in RA pathogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 5, 5 March 2008, Pages 579–585
Journal: FEBS Letters - Volume 582, Issue 5, 5 March 2008, Pages 579–585
نویسندگان
Tomohiro Koga, Takafumi Torigoshi, Satoru Motokawa, Taichiro Miyashita, Yumi Maeda, Minoru Nakamura, Atsumasa Komori, Yoshihiro Aiba, Takashi Uemura, Hiroshi Yatsuhashi, Hiromi Ishibashi, Katsumi Eguchi, Kiyoshi Migita,