کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051285 | 1074196 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-angiogenic properties of myo-inositol trispyrophosphate in ovo and growth reduction of implanted glioma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anti-angiogenic properties of myo-inositol trispyrophosphate in ovo and growth reduction of implanted glioma Anti-angiogenic properties of myo-inositol trispyrophosphate in ovo and growth reduction of implanted glioma](/preview/png/2051285.png)
چکیده انگلیسی
We investigate here the anti-angiogenic properties of the synthetic compound myo-inositol trispyrophosphate (ITPP). By increasing oxy-haemoglobin dissociation, ITPP has the potential to counteract the effects of hypoxia, a critical regulator of angiogenesis and cancer progression. ITPP inhibited angiogenesis of the chorioallantoic membrane (CAM), as analyzed with an original program dedicated to automated quantification of angiogenesis in this model. ITPP also markedly reduced tumor progression and angiogenesis in an experimental model of U87 glioma cell nodules grafted onto the CAM. These results point out the potential of ITPP for the development of a new class of anti-angiogenic and anti-cancer compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 5, 6 March 2007, Pages 962–966
Journal: FEBS Letters - Volume 581, Issue 5, 6 March 2007, Pages 962–966
نویسندگان
Gabin Sihn, Thomas Walter, Jean-Claude Klein, Isabelle Queguiner, Hiroshi Iwao, Claude Nicolau, Jean-Marie Lehn, Pierre Corvol, Jean-Marie Gasc,