کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051355 | 1074197 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility](/preview/png/2051355.png)
چکیده انگلیسی
Myocyte-specific enhancer factor 2A (MEF2A) regulates a broad range of fundamental cellular processes including cell division, differentiation and death. Here, we tested the hypothesis that MEF2A is required in cardiac contractility employing zebrafish as a model organism. MEF2A is highly expressed in heart as well as somites during zebrafish embryogenesis. Knock-down of MEF2A in zebrafish impaires the cardiac contractility and results in sarcomere assembly defects. Dysregulation of cardiac genes in MEF2A morphants suggests that sarcomere assembly disturbances account for the cardiac contractile deficiency. Our studies suggested that MEF2A is essential in cardiac contractility.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 21, 29 August 2005, Pages 4843–4850
Journal: FEBS Letters - Volume 579, Issue 21, 29 August 2005, Pages 4843–4850
نویسندگان
Yue-Xiang Wang, Lin-Xi Qian, Zhang Yu, Qiu Jiang, Yong-Xin Dong, Xue-Fei Liu, Xin-Ying Yang, Tao P. Zhong, Hou-Yan Song,