کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051387 | 1074198 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A novel family of single VWC-domain proteins in invertebrates A novel family of single VWC-domain proteins in invertebrates](/preview/png/2051387.png)
Using a combination of sequence analysis tools, a novel family of 13 short Drosophila melanogaster proteins with similarity to a single von Willebrand factor C-domain (SVC proteins) has been identified. SVCs are predicted to be secreted and a structural model for the family is proposed, using a known von Willebrand factor C-domain (VWC) structure as template. All SVCs possess eight cysteines, consistent with the loss of one bonded pair from the 10-cysteine canonical pattern of most VWC domains. Unlike most Drosophila genes, many SVCs are not expressed during development, and misexpression has no apparent effect on development or viability. SVCs appear to be restricted to arthropods. A role for SVCs in response to environmental challenges is proposed.
Journal: FEBS Letters - Volume 581, Issue 27, 13 November 2007, Pages 5268–5274