کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051428 1074200 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ICAM-3, a ligand for DC-SIGN, was duplicated from ICAM-1 in mammalian evolution, but was lost in the rodent genome
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
ICAM-3, a ligand for DC-SIGN, was duplicated from ICAM-1 in mammalian evolution, but was lost in the rodent genome
چکیده انگلیسی

ICAM-3 is a DC-SIGN ligand that is constitutively expressed on resting leukocytes, and is thus an important molecule for the first immune response. But, ICAM-3 has not been isolated form rodents. Thus, we compare the ICAM gene clusters in human, dog, mouse, and rat. ICAM-1, -4, -5 and -3 are located close to one another on the same chromosome and show genomic synteny in human and dog. Almost the same ICAM gene clusters were found in rodent genome, but only the ICAM-3 was not present. A phylogenetic tree plotting the cDNAs of human, dog, mouse, rat, and bovine suggested that ICAM-3 was made from a duplication of ICAM-1. Thus, ICAM-3 arose from ICAM-1 in the mammalian evolution, but was lost in the rodent’s genome. Our study suggests the different immune response in the rodents in comparison with other mammals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 13, 23 May 2005, Pages 2901–2906
نویسندگان
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