کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051500 | 1074202 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transcriptional suppression of nephrin in podocytes by macrophages: Roles of inflammatory cytokines and involvement of the PI3K/Akt pathway
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کلمات کلیدی
LPS, lipopolysacchaATRA, All-trans retinoic acid - ATRA، اسید کلرید رتینوئیکPKC, protein kinase C - PKC، پروتئین کیناز CSEAP, secreted alkaline phosphatase - SEAP، آلکالین فسفاتاز را ترشح می کندTPA, 12-O-tetradecanoylphorbol-13-acetate - TPA، 12-O-tetradecanoylphorbol-13-acetateFBS, fetal bovine serum - سرم جنینی گاوی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transcriptional suppression of nephrin in podocytes by macrophages: Roles of inflammatory cytokines and involvement of the PI3K/Akt pathway Transcriptional suppression of nephrin in podocytes by macrophages: Roles of inflammatory cytokines and involvement of the PI3K/Akt pathway](/preview/png/2051500.png)
چکیده انگلیسی
Expression of nephrin, a crucial component of the glomerular slit diaphragm, is downregulated in patients with proteinuric glomerular diseases. Using conditionally immortalized reporter podocytes, we found that bystander macrophages as well as macrophage-derived cytokines IL-1β and TNF-α markedly suppressed activity of the nephrin gene promoter in podocytes. The cytokine-initiated repression was reversible, observed on both basal and inducible expression, independent of Wilms’ tumor suppressor WT1, and caused in part via activation of the phosphatidylinositol-3-kinase/Akt pathway. These results indicated a novel mechanism by which activated macrophages participate in the induction of proteinuria in glomerular diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 3, 6 February 2007, Pages 421–426
Journal: FEBS Letters - Volume 581, Issue 3, 6 February 2007, Pages 421–426
نویسندگان
Yosuke Takano, Kozue Yamauchi, Kunihiro Hayakawa, Nobuhiko Hiramatsu, Ayumi Kasai, Maro Okamura, Makiko Yokouchi, Akihiro Shitamura, Jian Yao, Masanori Kitamura,