کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051576 | 1074204 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 6, 20 March 2007, Pages 1131–1136
Journal: FEBS Letters - Volume 581, Issue 6, 20 March 2007, Pages 1131–1136
نویسندگان
Ryoichi Banno, Hiroshi Arima, Masayuki Hayashi, Motomitsu Goto, Minemori Watanabe, Ikuko Sato, Nobuaki Ozaki, Hiroshi Nagasaki, Noriyuki Ozaki, Yutaka Oiso,