کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051591 1074204 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif ‘GUCE’
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif ‘GUCE’
چکیده انگلیسی

GTF2IRD1 is a member of a family of transcription factors whose defining characteristic is varying numbers of a helix–loop–helix like motif, the I-repeat. Here, we present functional analysis of human GTF2IRD1 in regulation of three genes (HOXC8, GOOSECOID and TROPONIN ISLOW). We define a regulatory motif (GUCE–GTF2IRD1 Upstream Control Element) common to all three genes. GUCE is bound in vitro by domain I-4 of GTF2IRD1 and mediates transcriptional regulation by GTF2IRD1 in vivo. Definition of this site will assist in identification of other downstream targets of GTF2IRD1 and elucidation of its role in the human developmental disorder Williams–Beuren syndrome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 6, 20 March 2007, Pages 1233–1242
نویسندگان
, , , , , , ,