کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051606 1074205 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Overrepresentation of interactions between homologous proteins in interactomes
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Overrepresentation of interactions between homologous proteins in interactomes
چکیده انگلیسی

It is well proved that the probability that a protein interacts with itself is higher than that it interacts with another protein. It has been recently shown that the probability of interaction is also higher for proteins with significant sequence similarity. In this paper we show that proteins sharing identical PFAM domains interact more often than expected by chance in Saccharomyces cerevisiae and Escherichia coli. We also analyze the variety of domain interfaces used by homologous proteins to interact and show that the overrepresentation of interactions between homological proteins is not caused by small number of pairs of identical “sticky domains” shared between interacting proteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 1, 9 January 2007, Pages 52–56
نویسندگان
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