کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051635 1074206 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction of metallothionein with tumor suppressor p53 protein
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Interaction of metallothionein with tumor suppressor p53 protein
چکیده انگلیسی

Previous reports have shown that metallothionein (MT) may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between MT and p53 in cells. The results demonstrate an interaction between MT and p53 can occur in vitro. The complex between MT and p53 was observed in breast cancer epithelial cells with both wild and inactive type of p53. Furthermore, it was shown that wt-p53 was preferentially associated with Apo-MT. Our data suggest that co-expression of MT and p53 and their complex formation in tumor cells may be involved in regulation of apoptosis in these cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 5, 20 February 2006, Pages 1235–1238
نویسندگان
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