کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051704 | 1074207 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ripply2 is essential for precise somite formation during mouse early development
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The regions of expression of Ripply1 and Ripply2, presumptive transcriptional corepressors, overlap at the presomitic mesoderm during somitogenesis in mouse and zebrafish. Ripply1 is required for somite segmentation in zebrafish, but the developmental role of Ripply2 remains unclear in both species. Here, we generated Ripply2 knock-out mice to investigate the role of Ripply2. Defects in segmentation of the axial skeleton were observed in the homozygous mutant mice. Moreover, somite segmentation and expression of Notch2 and Uncx4.1 were disrupted. These findings indicate that Ripply2 is involved in somite segmentation and establishment of rostrocaudal polarity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 14, 12 June 2007, Pages 2691–2696
Journal: FEBS Letters - Volume 581, Issue 14, 12 June 2007, Pages 2691–2696
نویسندگان
Techuan Chan, Akiko Kondow, Akihiro Hosoya, Keisuke Hitachi, Akira Yukita, Koji Okabayashi, Hiroaki Nakamura, Hidehiro Ozawa, Hiroshi Kiyonari, Tatsuo Michiue, Yuzuru Ito, Makoto Asashima,