کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051728 | 1074208 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selection for TRAIL resistance results in melanoma cells with high proliferative potential
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Selection for TRAIL resistance results in melanoma cells with high proliferative potential Selection for TRAIL resistance results in melanoma cells with high proliferative potential](/preview/png/2051728.png)
چکیده انگلیسی
To better understand the outcome of the interaction between TNF-related apoptosis-inducing factor (TRAIL) and tumor cells, we studied TRAIL-resistant melanoma cells resulting from prolonged exposure to TRAIL and found that they had higher proliferative activity than the parental cells both in vitro and in vivo. This was associated with reduced p53 and p21 expression and increased activation of Erk1/2 and Akt. Accelerated proliferation was not due to TRAIL-mediated signaling but appeared to be the result of selection of previously existing, characteristically distinct cells. Moreover, responses of p53 to stimulation in the TRAIL-resistant cells appeared to be impaired.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 9, 28 March 2005, Pages 1940–1944
Journal: FEBS Letters - Volume 579, Issue 9, 28 March 2005, Pages 1940–1944
نویسندگان
Jing Jing Wu, Xu Dong Zhang, Susan Gillespie, Peter Hersey,