کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051761 1074209 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The armadillo repeats of the Ufd4 ubiquitin ligase recognize ubiquitin-fusion proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The armadillo repeats of the Ufd4 ubiquitin ligase recognize ubiquitin-fusion proteins
چکیده انگلیسی

Armadillo (ARM) repeats have been identified in proteins regulating cell junction assembly, nuclear transport and transcription activation. Recent studies showed that a large number of ubiquitin (Ub) ligases (or E3s) also contain ARM repeats. The function of the ARM repeats in these E3s, however, remains unknown. Here we report that the ARM repeats of Ufd4, the E3 component of the UFD (Ub fusion degradation) pathway, recognize the Ub degradation signal of the UFD substrates. Disruption of the ARM repeats abolishes the ubiquitylating activity of Ufd4. This study uncovers a new role of the ARM repeats in protein ubiquitylation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 2, 23 January 2007, Pages 265–270
نویسندگان
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