کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051768 1074209 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNAAsn
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNAAsn
چکیده انگلیسی

The important identity elements in tRNAGln and tRNAAsn for bacterial GatCAB and in tRNAGln for archaeal GatDE are the D-loop and the first base pair of the acceptor stem. Here we show that Methanothermobacter thermautotrophicus GatCAB, the archaeal enzyme, is different as it discriminates Asp-tRNAAsp and Asp-tRNAAsn by use of U49, the D-loop and to a lesser extent the variable loop. Since archaea possess the tRNAGln-specific amidotransferase GatDE, the archaeal GatCAB enzyme evolved to recognize different elements in tRNAAsn than those recognized by GatDE or by the bacterial GatCAB enzyme in their tRNA substrates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 2, 23 January 2007, Pages 309–314
نویسندگان
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