کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051811 | 1074210 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rapid rates of newly synthesized mitochondrial protein degradation are significantly affected by the generation of mitochondrial free radicals
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
FACDMEM, Dulbecco?s modified Eagle?s mediaMTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide - MTT، 3- [4،5-dimethylthiazol-2-yl] -2،5-diphenyltetrazolium bromideROS, Reactive Oxygen Species - ROS، انواع اکسیژن واکنشیCFTR, cystic fibrosis transmembrane conductance regulator - تنظیمکننده هدایت تراغشایی فیبروز سیستیکFCS, fetal calf serum - سرم جنینی گاویPBS, phosphate buffered saline - محلول نمکِ فسفات با خاصیت بافری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Rapid rates of newly synthesized mitochondrial protein degradation are significantly affected by the generation of mitochondrial free radicals Rapid rates of newly synthesized mitochondrial protein degradation are significantly affected by the generation of mitochondrial free radicals](/preview/png/2051811.png)
چکیده انگلیسی
Exposure of biological material to high levels of free radicals causes extensive cellular damage. Reactive oxygen species (ROS) generated by mitochondria have been associated with a variety of diseases and aging. We investigated the effect of low-level mitochondrial ROS production on newly synthesized mitochondrial proteins which are potentially vulnerable to mitochondrial ROS due to their location and unfolded state. We show that elevated mitochondrial ROS increases the degradation of newly synthesized mitochondrial proteins with some proteins more sensitive than others. In the long term reduced assembly of mitochondrial complexes would affect mitochondrial function and may trigger a vicious cycle of mitochondrial ROS production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 28, 21 November 2005, Pages 6511–6517
Journal: FEBS Letters - Volume 579, Issue 28, 21 November 2005, Pages 6511–6517
نویسندگان
A. Basoah, P.M. Matthews, K.J. Morten,