کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051876 1074213 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GSK3 alpha and GSK3 beta are necessary for axon formation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
GSK3 alpha and GSK3 beta are necessary for axon formation
چکیده انگلیسی

The mechanisms that underlie axon formation are still poorly understood. GSK3 has been recently implicated in establishing the axon and in its elongation. We have used four different GSK3 inhibitors to determine the role of GSK3 activity in hippocampal neurons at different periods of time. Inhibition of GSK3 activity impairs axon formation. The “critical period” of this activity of GSK3 is at least the first 24 h since afterwards the inhibition of GSK3 does not compromise the process of elongation, although it exacerbates axon branching. Moreover, interference RNAs impeding the expression of the GSK3 alpha or beta isoforms in hippocampal neurons prevents an axon from forming.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 8, 17 April 2007, Pages 1579–1586
نویسندگان
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