کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051941 1074217 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Assembly of major histocompatibility complex class II subunits with invariant chain
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Assembly of major histocompatibility complex class II subunits with invariant chain
چکیده انگلیسی

The highly polymorphic major histocompatibility complex class II (MHCII) polypeptides assemble in the ER with the assistance of invariant chain (Ii) chaperone. Ii binds to the peptide-binding pocket of MHCII heterodimers. We explored the mechanism how MHCII subunits attach to Ii. Expression with single α or β subunits from three human HLA and two mouse H2 class II isotypes revealed that Ii co-isolates predominantly with the α polypeptide. Co-isolation with α chain requires the groove binding Ii-segment and depends on M91 of Ii. Immunoprecipitation of Ii from pulse chase labeled cells showed sequential assembly of α and β chains.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 27, 7 November 2005, Pages 6055–6059
نویسندگان
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