کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2051983 1074218 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
چکیده انگلیسی

Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 4, 20 February 2007, Pages 587–595
نویسندگان
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