کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2051996 | 1074218 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress](/preview/png/2051996.png)
چکیده انگلیسی
Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1-dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6 dyn/cm2, 24 h), nuclear exclusion of Foxo-1 by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang-1 expression were detected. In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 4, 20 February 2007, Pages 673–680
Journal: FEBS Letters - Volume 581, Issue 4, 20 February 2007, Pages 673–680
نویسندگان
Sven Chlench, Nigussie Mecha Disassa, Margret Hohberg, Christian Hoffmann, Theresa Pohlkamp, Gabriele Beyer, Mauro Bongrazio, Luis Da Silva-Azevedo, Oliver Baum, Axel Radlach Pries, Andreas Zakrzewicz,