کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052003 1074218 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells
چکیده انگلیسی

We show that a glycerophosphodiester phosphodiesterase homolog, GDE2, is widely expressed in brain tissues including primary neurons, and that the expression of GDE2 in neuroblastoma Neuro2A cells is significantly upregulated during neuronal differentiation by retinoic acid (RA) treatment. Stable expression of GDE2 resulted in neurite formation in the absence of RA, and GDE2 accumulated at the regions of perinuclear and growth cones in Neuro2A cells. Furthermore, a loss-of-function of GDE2 in Neuro2A cells by RNAi blocked RA-induced neurite formation. These results demonstrate that GDE2 expression during neuronal differentiation plays an important role for growing neurites.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 4, 20 February 2007, Pages 712–718
نویسندگان
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