کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052068 1074219 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor
چکیده انگلیسی

Previously, we reported that decreased brain-specific angiogenesis inhibitor 2 (BAI2) induced increased VEGF expression. The regulatory mechanisms for this process are not understood. Here we show that GA-binding protein gamma (GABPγ) associates with the cytoplasmic domain of BAI2, and GABPα/γ or GABPα/β works as a transcriptional repressor of VEGF in SHSY5Y cells. Transcriptional activity of wild-type VEGF promoter was significantly increased in anti-sense BAI2-transfected cells, but not that of VEGF promoter harboring mutated GABP sites. In in vivo focal cerebral ischemia model, the decrease in BAI2 accompanied by decreased GABPα and GABPγ elicited increased VEGF expression before the onset of HIF-1α. Our results point out that BAI2 controls VEGF transcription through GABP under normal conditions and cerebral ischemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 2, 23 January 2006, Pages 669–676
نویسندگان
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