کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052097 1074221 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Specificity of DC-SIGN for mannose- and fucose-containing glycans
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Specificity of DC-SIGN for mannose- and fucose-containing glycans
چکیده انگلیسی

The dendritic cell specific C-type lectin dendritic cell specific ICAM-3 grabbing non-integrin (DC-SIGN) binds to “self” glycan ligands found on human cells and to “foreign” glycans of bacterial or parasitic pathogens. Here, we investigated the binding properties of DC-SIGN to a large array of potential ligands in a glycan array format. Our data indicate that DC-SIGN binds with Kd < 2 μM to a neoglycoconjugate in which Galβ1-4(Fucα1-3)GlcNAc (Lex) trisaccharides are expressed multivalently. A lower selective binding was observed to oligomannose-type N-glycans, diantennary N-glycans expressing Lex and GalNAcβ1-4(Fucα1-3)GlcNAc (LacdiNAc-fucose), whereas no binding was observed to N-glycans expressing core-fucose linked either α1-6 or α1-3 to the Asn-linked GlcNAc of N-glycans. These results demonstrate that DC-SIGN is selective in its recognition of specific types of fucosylated glycans and subsets of oligomannose- and complex-type N-glycans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 26, 13 November 2006, Pages 6123–6131
نویسندگان
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