کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052168 1543466 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effect of acetyl-l-carnitine against oxidative stress induced by antiretroviral drugs
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Protective effect of acetyl-l-carnitine against oxidative stress induced by antiretroviral drugs
چکیده انگلیسی

Both HIV infection per se and antiretroviral drugs might contribute to oxidative stress and mitochondrial dysfunctions. In this study we assess zidovudine, stavudine and didanosine on U937 and CEM cell lines. All these drugs induced apoptosis and increased intracellular hydrogen peroxide but not superoxide anions. The addition of acetyl-l-carnitine (ALC) was able to prevent the pro-oxidant effect of the drugs tested. Supplementation with ALC, deficient in certain cohorts of HIV-infected individuals, especially on high active antiretroviral therapy regimen, has been associated with favourable effects. These data suggest that one of these effects could be a direct anti-oxidant action.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issues 28–29, 11 December 2006, Pages 6612–6616
نویسندگان
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