کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052347 1074228 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage
چکیده انگلیسی

Genes including DM domain regulate sexual development in diverse metazoan phyla. One of these genes, Dmrt7, was expressed only in testes of adult mice. To determine the role of Dmrt7 in mice, we generated Dmrt7-knockout mice (Dmrt7−/−). Although the Dmrt7−/− showed normal growth, null males were infertile. No sperm was detected in the epididymis of Dmrt7−/− adult males. Absence of spermatids in a histological analysis, decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7-knockout mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 27, 27 November 2006, Pages 6442–6446
نویسندگان
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