کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052356 1074228 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ErbB2 overexpression in p53-inactivated mammary epithelial cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
ErbB2 overexpression in p53-inactivated mammary epithelial cells
چکیده انگلیسی

Functional loss of p53 and ErbB2 overexpression are the frequent genetic alterations in human breast carcinomas. Here, we found that ErbB2 expression was upregulated in primary cultured mammary epithelial cells (MECs) isolated from mice with a defect in exons 5 and 6 of the p53 gene (p53Δ5,6). The reporter gene activity in the p53Δ5,6 MECs transfected with the −756 bp flanking region of the hErbB2 gene was higher than the wild type MECs. p53 inactivation selectively increased the level of AP-2α, but not AP-2β and AP-2γ and a mutation of the two AP-2 binding sites completely inhibited the reporter activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 27, 27 November 2006, Pages 6501–6508
نویسندگان
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