کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052376 1074229 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome-associated coronavirus
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome-associated coronavirus
چکیده انگلیسی

SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS-CoV accessory protein, did not elicit synergistic effects on DNA synthesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 15, 26 June 2006, Pages 3643–3648
نویسندگان
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