کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052386 1074229 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Goat SRY induces testis development in XX transgenic mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Goat SRY induces testis development in XX transgenic mice
چکیده انگلیسی

The testis-determining gene SRY is not well-conserved among mammals, particularly between mouse and other mammals, both in terms of protein structure and of expression regulation. To evaluate SRY phylogenic conservation in regards to its function, we expressed the goat gene (gSRY) in XX transgenic mouse gonads. Here, we show that gSRY induces testis formation, despite a goat expression profile. Our results demonstrate that sex-reversal can be induced in XX-mice by a non-mouse SRY thus suggesting a conserved molecular mechanism of action of this testis-determining gene across mammalian species.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 15, 26 June 2006, Pages 3715–3720
نویسندگان
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