کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052486 | 1074231 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of the rat brain Na+-driven Cl-/HCO3- exchanger involves protein kinase A and a multiprotein signaling complex
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regulation of the rat brain Na+-driven Cl-/HCO3- exchanger involves protein kinase A and a multiprotein signaling complex Regulation of the rat brain Na+-driven Cl-/HCO3- exchanger involves protein kinase A and a multiprotein signaling complex](/preview/png/2052486.png)
چکیده انگلیسی
The Na+-driven Cl-/HCO3- exchanger (NCBE) plays an important role in the regulation of intracellular pH (pHi). We previously identified two variants of NCBE from rat brain of which the variant with a carboxyterminal PSD-95/Dlg/ZO-1 (PDZ) motif (rb2NCBE) colocalized with the actin cytoskeleton. Increased rb2NCBE activity by PKA inhibition and reduction by forskolin and cAMP agonist suggest PKA regulation of NCBE. Disruption of actin filaments also decreased rb2NCBE activity. EBP50 and FLAG-rb2NCBE were reciprocally co-immunoprecipitated from rb2NCBE transfected cells. It is concluded that NCBE activity is inhibited by PKA and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 20, 4 September 2006, Pages 4865–4871
Journal: FEBS Letters - Volume 580, Issue 20, 4 September 2006, Pages 4865–4871
نویسندگان
Yong-Sun Lee, Yi-Bing Ouyang, Rona G. Giffard,