کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052789 | 1074240 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor](/preview/png/2052789.png)
چکیده انگلیسی
Ribonuclease A (RNase A) dimers have been recently found to be endowed with some of the special, i.e., non-catalytic biological activities of RNases, such as antitumor and aspermatogenic activities. These activities have been so far attributed to RNases which can escape the neutralizing action of the cytosolic RNase inhibitor (cRI). However, when the interactions of the two cytotoxic RNase A dimers with cRI were investigated in a quantitative fashion and at the molecular level, the dimers were found to bind cRI with high affinity and to form tight complexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 12, 9 May 2005, Pages 2663–2668
Journal: FEBS Letters - Volume 579, Issue 12, 9 May 2005, Pages 2663–2668
نویسندگان
Mariarosaria Naddeo, Luigi Vitagliano, Aniello Russo, Giovanni Gotte, Giuseppe D’Alessio, Salvatore Sorrentino,