کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052950 | 1074245 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Casein kinase Iε associates with and phosphorylates the tight junction protein occludin
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Casein kinase Iε associates with and phosphorylates the tight junction protein occludin Casein kinase Iε associates with and phosphorylates the tight junction protein occludin](/preview/png/2052950.png)
چکیده انگلیسی
Occludin is an integral-membrane protein that contributes to tight junction function. We have identified casein kinase Iε (CKIε) as a binding partner for the C-terminal cytoplasmic domain of occludin by yeast two-hybrid screening. CKIε phosphorylated occludin and co-localised and co-immunoprecipitated with occludin from human endothelial cells. Amino acids 265–318 of occludin were sufficient for CKIε binding and phosphorylation. Deletion of the C-terminal 48 amino acids of occludin increased CKIε binding and phosphorylation, suggesting that this region inhibits CKIε binding. These data identify CKIε as a novel occludin kinase that may be important for the regulation of occludin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 9, 17 April 2006, Pages 2388–2394
Journal: FEBS Letters - Volume 580, Issue 9, 17 April 2006, Pages 2388–2394
نویسندگان
Jenny A.G. McKenzie, Kirsi Riento, Anne J. Ridley,