کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052982 | 1074249 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein](/preview/png/2052982.png)
Expression of androgen receptor (AR) in prostate epithelial cells is thought to regulate cell proliferation, differentiation, and survival. However, the molecular mechanisms remain unclear. We report that re-expression of AR in PC-3 human prostate cancer cell line resulted in upregulation of IFI16 protein, a negative regulator of cell growth. We found that the IFI16 protein bound to AR in a ligand-dependent manner and the DNA-binding domain (DBD) of the AR was sufficient to bind IFI16. Furthermore, re-expression of IFI16 protein in LNCaP prostate cancer cells, which do not express IFI16 protein, resulted in downregulation of AR expression and an inhibition of the expression of AR target genes. Our observations identify a role for IFI16 protein in AR-mediated functions.
Journal: FEBS Letters - Volume 580, Issue 6, 6 March 2006, Pages 1659–1664