کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2053006 1074251 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells
چکیده انگلیسی

Activation of an over-expressed mutant form of the tumour suppressor protein p53 has been shown to inhibit protein synthesis. To determine whether this effect is due only to high level expression or the mutant nature of the protein, we have used a doxycycline-inducible lung carcinoma cell line capable of expressing wild-type p53. We now show that levels of wild-type p53 similar to those expressed endogenously also inhibit protein synthesis. The mechanism involves dephosphorylation and accumulation of the translational inhibitor 4E-BP1, and increased association of 4E-BP1 with initiation factor eIF4E. The inhibition of translation is not a consequence of p53-mediated apoptosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 7, 20 March 2006, Pages 1766–1770
نویسندگان
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