کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2053014 1074251 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of the nuclear export signal in the helix–loop–helix inhibitor Id1
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Identification of the nuclear export signal in the helix–loop–helix inhibitor Id1
چکیده انگلیسی

Id proteins play important roles in cellular differentiation and proliferation by negatively regulating basic helix–loop–helix transcription factors. Although their intracellular localization may change depending on the biological situation, little is known about the molecular determinants underlying such changes. Here we report the identification of a nuclear export signal (NES) in Id1. The identified NES was different from that of Id2, but had the ability to confine heterologous green fluorescent protein to the cytoplasm. Thus, our results indicate that the intracellular localization of Id1 is regulated differently from that of Id2.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 7, 20 March 2006, Pages 1812–1816
نویسندگان
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