کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2053026 | 1074251 | 2006 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Epigallocatechin-3-gallate protects toluene diisocyanate-induced airway inflammation in a murine model of asthma Epigallocatechin-3-gallate protects toluene diisocyanate-induced airway inflammation in a murine model of asthma](/preview/png/2053026.png)
Epigallocatechin-3-gallate (EGCG), a major form of tea catechin, has anti-allergic properties. To elucidate the anti-allergic mechanisms of EGCG, we investigated its regulation of matrix metalloproteinase (MMP-9) expression in toluene diisocyanate (TDI)-inhalation lung tissues as well as TNF-α and Th2 cytokine (IL-5) production in BAL fluid. Compared with untreated asthmatic mice those administrated with EGCG had significantly reduced asthmatic reaction. Also, increased reactive oxygen species (ROS) generation by TDI inhalation was diminished by administration of EGCG in BAL fluid. These results suggest that EGCG regulates inflammatory cell migration possibly by suppressing MMP-9 production and ROS generation, and indicate that EGCG may be useful as an adjuvant therapy for bronchial asthma.
Journal: FEBS Letters - Volume 580, Issue 7, 20 March 2006, Pages 1883–1890