کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2054082 | 1543716 | 2011 | 8 صفحه PDF | دانلود رایگان |
Invasive aspergillosis mostly caused by the opportunistic mould Aspergillus fumigatus is characterized by high morbidity and mortality in risk group patients. Several ethno-pathological factors promote the development and the course of this fungal infection like neutropenia, T-cell depletion, CD34-selected stem cell products, corticosteroid therapy, or cytomegalovirus infections. Furthermore, a growing number of defined single nucleotide polymorphisms affiliated to genes affecting the innate immune response has been described which genetically determine susceptibility to A. fumigatus. Thereby, it concerns a broad band ranging from genes encoding for cytokines or chemokines, their respective receptors to those of toll-like receptors including further genes involved in recognition and defence of pathogens by the innate immune system. Here, we summarize in detail the current knowledge about genetic markers correlated with invasive aspergillosis and their relevance for the developing and outcome of infections with A. fumigatus.
Journal: International Journal of Medical Microbiology - Volume 301, Issue 5, June 2011, Pages 445–452