کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2062441 | 1076607 | 2015 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Tauroursodeoxycholic acid improves the implantation and live-birth rates of mouse embryos Tauroursodeoxycholic acid improves the implantation and live-birth rates of mouse embryos](/preview/png/2062441.png)
We previously demonstrated that tauroursodeoxycholic acid (TUDCA) improved the developmental competence of mouse embryos by attenuating endoplasmic reticulum (ER) stress-induced apoptosis during preimplantation development. Here, we present a follow-up study examining whether TUDCA enhances the implantation and live-birth rate of mouse embryos. Mouse 2-cell embryos were collected by oviduct flushing and cultured in the presence or absence of 50 μM TUDCA. After culture (52 h), blastocysts were transferred to 2.5-day pseudopregnant foster mothers. It was found that the rates of pregnancy and implantation as well as the number of live pups per surrogate mouse were significantly higher in the TUDCA-treated group compared to the control group, but there was no significant difference in the mean weights of the pups or placentae. Thus, we report for the first time that TUDCA supplementation of the embryo culture medium increased the implantation and livebirth rates of transferred mouse embryos.
Journal: Reproductive Biology - Volume 15, Issue 2, June 2015, Pages 101–105