Keywords: Intrahepatic cholestasis of pregnancy; Serum bile acid; Pseudo-targeted method; Metabolomics; UPLC-triple TOF-MS/MS; Diagnostic and therapeutic profiles; ICP; Intrahepatic cholestasis of pregnancy; TBA; total bile acids; UDCA; ursodeoxycholic acid; LCA; l
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Keywords: Sex differences; Steroids; Gut microbiota; Metabolic disease; Cardiovascular disease; ApoE; apolipoprotein E; BAs; bile acids; CVD; cardiovascular diseases; E1; estrone; E2; estradiol; E3; estriol; ER; estrogen receptor; FCG; four core genotypes; FMO3; fl
Keywords: ATM; ataxia telangiectasia mutated; ATR; ATM-Rad3-related; AMPK; AMP-activated protein kinase; AD; Alzheimer's disease; ARE; antioxidant response element; ATF6; activating transcription factor 6; BiP; binding immunoglobulin protein; BRAC1; Breast cancer 1
Keywords: ASC; apoptosis-associated speck-like protein containing a CARD; ATF6; activating transcription factor 6; CHOP; C/EBP homologous protein; DAMPs; damage-associated molecular patterns; gAcrp; globular adiponectin; HBSS; Hank's balanced salt solution; HO-1;
Keywords: ASBT; apical sodium-dependent bile acid transporter; ASDs; amorphous solid dispersions; BACS; bile acid-CoA synthase; BAT; bile acid-amino acid transferase; BCS; biopharmaceutics classification system; BSH; bile salt hydrolase; C4; 7α-hydroxy-4-cholesten
Keywords: PGMO; Pre-gestational maternal obesity; PGMN; Pre-gestational maternal normal weight; HUVECs; Human umbilical vein endothelial cells; NO; Nitric oxide; NOS; Nitric oxide synthase; eNOS; endothelial nitric oxide synthase; Akt; Protein kinase B/Akt; ER; end
Keywords: Neuroprotection; Retina; TUDCA; Dopamine; Exercise; Electrical stimulation;
Keywords: Benchmark dose modeling; DNA methylation; LINE-1; miRNA; Metabolomics; Hepatotoxicants; Dose-response; Ahr; Aryl Hydrocarbon receptor; BA; Bile Acid; BMD; Benchmark Dose; BrdU; Bromodeoxyuridine; CAR; Constitutive Androgen Receptor; CF; Clofibrate; ChIP;
Keywords: Amiloidosis cardiaca; Transtiretina; Senil; Hereditaria; Cardiac amyloidosis; Transthyretin; Senile; Hereditary; ATTRm; amiloidosis por transtiretina, forma hereditaria; ATTRwt; amiloidosis por transtiretina, forma natural; HVI; hipertrofia ventricular iz
Keywords: Cardiac amyloidosis; Transthyretin; Senile; Hereditary; Amiloidosis cardiaca; Transtiretina; Senil; Hereditaria; ATTRm; mutant transthyretin amyloidosis; ATTRwt; wild-type transthyretin amyloidosis; CTS; carpal tunnel syndrome; HCM; hypertrophic cardiomyo
Keywords: cTnT; Cardiac troponin T; CPHPC; R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid; EGCG; epigallocethechin-3-gallate; FLC-diff; difference between involved and uninvolved serum free light chain; FDA; Food and Drug Administ
Keywords: DCA; deoxycholic acid; βMCA; β-muricholic acid; CA; cholic acid; CDCA; chenodeoxycholic acid; HDCA; hyodeoxycholic acid; ID; iron depletion; Rif; rifampicin; TUDCA; tauroursodeoxycholic acid; TCDCA; taurochenodeoxycholic acid; TDCA; taurodeoxycholic a
Keywords: TUDCA; Parkinson's disease; Oxidative stress; Mitochondria; Mitophagy; Parkin;
Keywords: Bile acid; ER stress; TUDCA; Cytoprotection; Liver; Fluorescent reporter;
Keywords: ATF4; activating transcription factor-4; ATF6α; activating transcription factor-6α; EB1; end binding protein-1; EDEM; ER degradation-enhancing α-like protein; ER; endoplasmic reticulum; ERAD; ER-associated degradation; GCN2; general control non-derepre
Keywords: BiP; Binding protein; CCL2; Chemokine (C-C motif) ligand 2; CCL3; Chemokine (C-C motif) ligand 3; CCL5; Chemokine (C-C motif) ligand 5; C/EBP; CCAAT/enhancer binding protein; CHOP; C/EBP homologous protein; Ct; Comparative threshold cycle;; eIF2α; Eukary
Keywords: ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
Keywords: BMI; body mass index; CRP; C-reactive protein; db/db; diabetic; ER; endoplasmic reticulum; HSP; heat shock proteins; JAK; janus kinase; ob/ob; obese; LEPR; leptin receptor; MAPK; mitogen-activated protein kinase; mTOR; mammalian target of rapamycin; NK; n
Keywords: di-4-ANEPPDHQ; 1-[2-Hydroxy-3-(N,N-di-methyl-N-hydroxyethyl)ammoniopropyl]-4-[β-[2-(di-n-butylamino)-6-napthyl] vinyl]pyridinium dibromide; BA(s); Bile acid(s); Bax; Bcl-2-associated X protein; CDCA; Chenodeoxycholic acid; Chol; Cholesterol; DCA; Deoxych
Keywords: ANT; adenine nucleotide translocator; Cyt C; cytochrome C; Cys A; cyclosporine A; FCCP; carbonylcyanide-p-(trifluoromethoxy) phenyl-hydrazone; GCDCA; glycochenodeoxycholic acid; IM; inner membrane; MβCD; methyl-β-cyclodextrin; MMP; mitochondrial membran
Tauroursodeoxycholic acid binds to the G-protein site on light activated rhodopsin
Keywords: Bile acid; Chemical biology; G protein; G proteinâcoupled receptor (GPCR); Molecular docking; Photoreceptor; Phototransduction; Retina; Rhodopsin; Signal transduction; GPCR; G-protein coupled receptor; G-protein; heterotrimeric GTP-binding protein; R; d
Targeting the enhanced ER stress response in Marinesco-Sjögren syndrome
Keywords: Marinesco-Sjögren syndrome; ER stress; Lymphoblastoid cell line; Tunicamycin; Apoptosis; Tauroursodeoxycholic acid; 4-PBA; sodium phenylbutyrate; ATF6α; activating transcription factor 6α; CASP3; caspase-3; DEXA; dexamethasone; EBV; Epstein-Barr virus;
Rab7a modulates ER stress and ER morphology
Keywords: BiP; binding immunoglobulin protein; CHOP; CCAAT-enhancer-binding protein homologous protein; CLIMP63; 63-kDa cytoskeleton-linking membrane protein; ER; endoplasmic reticulum; LEs; late endosomes; GDP; guanine diphosphate; GTP; guanine triphosphate; NT; n
Portal myofibroblasts are sensitive to CCN-mediated endoplasmic reticulum stress-related apoptosis with potential to attenuate biliary fibrogenesis
Keywords: CCN proteins; ER stress; Unfolded protein response; Matricellular proteins; Portal myofibroblasts; TUDCA; α-SMA; α-smooth muscle actin; ATF6; activating transcription factor 6; BDL; bile duct ligation; eIF2α; eukaryotic translation initiation factor 2Î
Acquired transthyretin amyloidosis after domino liver transplant: Phenotypic correlation, implication of liver retransplantation
Keywords: ATTRm; mutated transthyretin amyloidosis; DLT; Domino liver transplant; EF; ejection fraction; GI; Gastrointestinal; IVS; Interventricular septum; LV; left ventricle; MS/MS; tandem mass spectrometry; OLT; Orthotopic liver transplantation; TTR; Transthyret
Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation
Keywords: COX-2; cyclooxygenase-2; PE; phenylephrine; ER; Endoplasmic reticulum; 4-BPA; 4-phenyl butyric acid; TUDCA; Tauroursodeoxycholic Acid Sodium; PGE2; prostaglandin E2; PGI2; prostaglandin I2; TxA2; thromboxane A2; Ceramide; ER stress; COX-2; Vasoconstrictio
ER stress disturbs SR/ER-mitochondria Ca2Â + transfer: Implications in Duchenne muscular dystrophy
Keywords: ATF6; activating transcription factor 6; ATP; Adenosine triphosphate; CTL; Control; Ddit3; DNA damage inducible transcript 3; DMD; Duchenne Muscular Dystrophy; EDL; Extensor Digitorum Longus; EIF2α; eukaryotic translation initiation factor 2A; FBS; fetal
Identification of Bile Acids Responsible for Inhibiting the Bile Salt Export Pump, Leading to Bile Acid Accumulation and Cell Toxicity in Rat Hepatocytes
Keywords: biliary excretion; in vitro models; toxicology; bile acid transporters; efflux pumps; BA; bile acid; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; CsA; cyclosporin A; DCA; deoxycholic acid; DILI; drug-induced liver injury; DM
Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response
Keywords: RFP; rifampicin; TUDCA; tauroursodeoxycholic acid; Nrf2; nuclear factor erythroid 2-related factor; DILI; drug-induced liver injury; ALF; acute liver failure; TB; tuberculosis; INH; isoniazid; GSH; glutathione; BAs; bile acids; ER; endoplasmic reticulum;
Nox4 regulates the eNOS uncoupling process in aging endothelial cells
Keywords: eNOS; endothelial nitric oxide synthase; HUVEC; human umbilical vein endothelial cells; NO; nitric oxide; Nox4; NADPH oxidase 4; ROS; reactive oxygen species; NAC; N-acetyl cysteine; TUDCA; tauroursodeoxycholic acid; 4-PBA; 4-phenylbutyric acid; ER; endop
Improved synthesis of glycine, taurine and sulfate conjugated bile acids as reference compounds and internal standards for ESI-MS/MS urinary profiling of inborn errors of bile acid synthesis
Keywords: EEDQ; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; DEPC; diethyl phosphorocyanidate; DPPA; diphenyl phosphoryl azide; SO3-TEA; sulfur trioxide-triethylamine complex; SO3-TMA; sulfur trioxide-trimethylamine complex; SO3-DMA; sulfur trioxide-N,N-dimethyl
Targeting chaperones, heat shock factor-1, and unfolded protein response: Promising therapeutic approaches for neurodegenerative disorders
Keywords: 17-AAG; 17-(allylamino)-17-demethoxygeldanamycin (tanespimycin); 17-DMAG; 17- dimethylaminoethylamino-17-demethoxygeldanamycin (alvespimycin); AAV; adeno-associated virus; Aβ; amyloid-β; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP;
Original articleTauroursodeoxycholic acid improves pre-implantation development of porcine SCNT embryo by endoplasmic reticulum stress inhibition
Keywords: Porcine SCNT embryos; Endoplasmic reticulum stress; TUDCA; XBP1; Apoptosis;
Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway
Keywords: AMPK; ER stress; NLRP3 inflammasome; Quercetin; Quercetin-3-O-glucuronide; Tau phosphorylation; Compound C (PubChem CID: 11524144); Metformin (PubChem CID: 14219); Okadaic acid (PubChem CID: 446512); Quercetin (PubChem CID: 5280343); Quercetin-3-O-glucuro
Tauroursodeoxycholic acid improves the implantation and live-birth rates of mouse embryos
Keywords: TUDCA; Implantation; Embryo transfer; Mouse embryo
Bardet-Biedl syndrome: A model for translational research in rare diseases
Keywords: AAV; adeno-associated vector; ADPKD; autosomal dominant polycystic kidney disease; BBS; Bardet-Biedl Syndrome; CDE; common data element; CRIBBS; Clinical Registry Investigating Bardet-Biedl Syndrome; DDAVP; desmopressin acetate; GRDR®; Global Rare Di
Tauroursodeoxycholic acid prevents stress induced aggregation of proteins in vitro and promotes PERK activation in HepG2 cells
Keywords: TUDCA; PERK; UPR; BSA; Protein aggregation; LC–MS/MS; COX1; EcoR1
Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset
Keywords: Amyloid-β; Amyloid precursor protein; APP/PS1 mice; Glycogen synthase kinase β; Gliosis; Tau; TUDCA;
Research reportIncreased expression of phosphorylated c-Jun and phosphorylated c-Jun N-terminal kinase associated with neuronal cell death in diabetic and high glucose exposed rat retinas
Keywords: DR; diabetic retinopathy; ER; endoplasmic reticulum; PERK; PKR-like ER kinase; CHOP; C/EBP homologus protein; JNK; c-Jun N-terminal kinase; AP-1; activator protein-1; NT-4; neurotrophin-4; TUDCA; Taurine-conjugated ursodeoxycholic acid; STZ; streptozotoci
Research ArticleHepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice
Keywords: NAFLD; Non-alcoholic fatty liver disease; TG; triglyceride; ER; endoplasmic reticulum; THA; thapsigargin; Tun; tunicamycin; TUDCA; tauroursodeoxycholate; MPH; mouse primary hepatocyte; FXR; farnesoid X receptor; HNF1α; hepatocyte nuclear factor 1 alpha;
UPLC-MS-based serum metabonomics for identifying acute liver injury biomarkers in Chinese miniature pigs
Keywords: ALB; albumin; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ATP; adenosine triphosphate; BPI; base peak intensity; CDP-choline; cytidine diphosphate choline; CHO; cholesterol; Cr; creatinine; ESI; electrospray ionization; FAAH; fatty aci
Chemical chaperones reduce ionizing radiation-induced endoplasmic reticulum stress and cell death in IEC-6 cells
Keywords: ER; endoplasmic reticulum; UPR; unfolded protein response; eIF2α; eukaryotic translation initiation factor 2α; ATF4; activating transcription factor 4; PERK; RNA-dependent-protein-kinase-like ER kinase; PBA; 4-phenylbutyric acid; siRNA; small interferin
Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis
Keywords: StAR; steroidogenic acute regulatory protein; START; StAR-related lipid transfer; STARD10/Stard10; START domain containing 10; WT; wild type; ASBT/Asbt; apical sodium dependent bile acid transporter; STARD2/Stard2; START domain containing 2; CA; cholic ac
Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice
Keywords: Alzheimer's disease; APP/PS1; TUDCA; Learning and memory; Morris water maze
Ursodeoxycholic acid suppresses mitochondria-dependent programmed cell death induced by sodium nitroprusside in SH-SY5Y cells
Keywords: UDCA; ursodeoxycholic acid; TUDCA; tauroursodeoxycholic acid; YS; Yoo's solution; SNP; sodium nitroprusside; ROS; reactive oygen species; RNS; reactive nitrogen species; NO; nitric oxide; PD; Parkinson's disease; PI3K; phosphatidylinositol-3-kinase; PKA;
Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin
Keywords: FTI; farnesyltransferase inhibitor; MEF; mouse embryonic fibroblasts; TcdBF; toxin B from the Clostridium difficile serotype F strain 1470; TcsL; lethal Toxin from Clostridium sordellii; TUDCA; tauroursodesoxycholic acid; Glucosyltransferase; Apoptosis; C
Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response
Keywords: ATF6; activating transcription factor 6; CRP; C-reactive protein; CO; carbon monoxide; CORM-2; CO-releasing molecule-2 (tricarbonyl dichlororuthenium dimer); CORM-3; CO-releasing molecule-3 (tricarbonylchliro(glycinate)ruthenium); CREBH; cyclic AMP respon
Orexin neurons in hypothalamic slice cultures are vulnerable to endoplasmic reticulum stress
Keywords: hypocretin; neuropeptide turnover; ER-associated degradation; cycloheximide; tauroursodeoxycholic acid; ATF6; activating transcription factor 6; Bip; immunoglobulin G heavy chain-binding protein; CGRP; calcitonin gene-related peptide; CHOP; C/EBP-homologo
Bile acid toxicity structure-activity relationships: Correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A)
Keywords: GCA; glcyocholic acid; GCDCA; glycochenodeoxycholic acid; GDCA; glycodeoxycholic acid; GUDCA; glycoursodeoxycholic acid; HSA; hydrophobic surface area; HCA; hyocholic acid; NCA; nutriacholic acid; UCA; ursocholic acid; PSA; polar surface area; TCA; tauroc
Targeting post-mitochondrial effectors of apoptosis for neuroprotection
Keywords: ABD; ATP-binding domain; AIF; apoptosis-inducting factor; ANT; adenine nucleotide translocase; Antp HD; antennapedia homeodomain; Apaf-1; apoptotic peptidase activating factor 1; BH; Bcl-2 homology; BIR; baculoviral IAP repeat; boc-D-fmk; boc-Asp(OMe)-fmk