Orexin neurons in hypothalamic slice cultures are vulnerable to endoplasmic reticulum stress

▶Effect of ER stress inducers was examined in hypothalamic slice cultures. ▶ER stress inducers caused selective loss of orexin. ▶Loss of orexin at early stage resulted from depletion of stored orexin. ▶Loss of orexin at later stage resulted from degeneration of orexin neurons. ▶ER stress might be relevant to pathogenic events in narcolepsy.