کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2065763 | 1076938 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: 6,11-Dideoxytetrodotoxin from the puffer fish, Fugu pardalis 6,11-Dideoxytetrodotoxin from the puffer fish, Fugu pardalis](/preview/png/2065763.png)
The presence of an unknown dideoxy analog of tetrodotoxin was suggested on the liquid chromatography/electrospray ionization-mass spectrometry mass chromatogram of the ovaries of the puffer fish, Fugu pardalis, in single ion monitoring mode to detect at m/z 288. We succeeded to isolate this analog (approximately 0.4 mg) from 200 g of the ovaries and the structure was determined as 6,11-dideoxytetrodotoxin by spectroscopic methods (high resolution-fast atom bombardment-MS and NMR spectroscopy). The discovery of the new analog is highly significant with respect to the biosynthesis or metabolism of tetrodotoxin. We also roughly determined the value of IC50 (mice, intraperitoneal) for 6,11-dideoxytetrodotoxin as 420 μg/kg and thus it is 42 times less toxic than tetrodotoxin.
Journal: Toxicon - Volume 50, Issue 7, 1 December 2007, Pages 947–951