کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2067143 | 1544338 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells
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کلمات کلیدی
RealgarAPLATORNPNBTphorbol 12-myristate 13-acetateHL-60PMA - LDC هاMAPK - MAPKnitroblue tetrazolium - tetrazolium nitrobluearsenic trioxide - آرسنیک تریاکسیدDifferentiation - تفکیکarsenic sulfide - سولفید آرسنیکAPL, acute promyelocytic leukemia - لوسمی پرومیلوسیتیک حادMAPK pathway - مسیر MAPKmitogen-activated protein kinase - پروتئین کیناز فعال با mitogen
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells](/preview/png/2067143.png)
چکیده انگلیسی
The clinical efficacy and safety of realgar (arsenic sulfide, As4S4) in the treatment of acute promyelocytic leukemia in China have given rise to an upsurge in research on the underlying mechanism. We prepared realgar nanoparticles (RNPs) to examine their effect on the differentiation of HL-60 cells. Treatment with RNPs at 6 μM for 72 h induced cell differentiation that was assessed by morphological change, NBT reductive ability, and elevation of CD11b expression at both mRNA and protein levels. The RNP-induced differentiation was synergized, enhanced and suppressed by the inhibition of p38 MAPK, JNK and ERK pathways, respectively. Our findings demonstrate that MAPK signaling pathways are closely related to the RNP-induced differentiation in HL-60 cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 32, Issue 12, December 2008, Pages 1497-1505
Journal: Cell Biology International - Volume 32, Issue 12, December 2008, Pages 1497-1505
نویسندگان
Nan Wang, Li-Wen Wang, Bao-Di Gou, Tian-Lan Zhang, Kui Wang,