کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2067857 1077914 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Algal toxin yessotoxin signalling pathways involve immunocyte mussel calcium channels
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Algal toxin yessotoxin signalling pathways involve immunocyte mussel calcium channels
چکیده انگلیسی
A fragment of a putative L-type Ca2+ channel has been identified by molecular biology experiments in immunocytes from the mussel Mytilus galloprovincialis. Using the cell permeable and Ca2+-specific fluorochrome FURA 2-AM, we have demonstrated that the algal toxin yessotoxin (YTX) is able to increase intracellular Ca2+ concentration in M. galloprovincialis immunocytes. The YTX effect on Ca2+ increase is inhibited by the L-type Ca2+ channel inhibitor, verapamil, which is cAMP- and cGMP-dependent, but PKA- and nitric oxide-independent. On the basis of these observations, a possible role for YTX as a potential disturber of mussel immune efficiency is suggested.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 30, Issue 9, September 2006, Pages 721-726
نویسندگان
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