کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2067959 | 1077920 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
1,25-Dihydroxyvitamin D3 inhibits tumor necrosis factor-α-induced adhesion molecule expression in endothelial cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 1,25-Dihydroxyvitamin D3 inhibits tumor necrosis factor-α-induced adhesion molecule expression in endothelial cells 1,25-Dihydroxyvitamin D3 inhibits tumor necrosis factor-α-induced adhesion molecule expression in endothelial cells](/preview/png/2067959.png)
چکیده انگلیسی
This study tested the hypothesis that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] plays a role in human umbilical vein endothelial cells (HUVEC) cultures. HUVEC were incubated with 10 or 100 nM 1,25(OH)2D3 for 24 h, in the absence or presence of 40 ng/ml tumor necrosis factor-α (TNF-α) or 2 ng/ml interleukin-1α (IL-1α). 1,25(OH)2D3 did not affect HUVEC viability and proliferation, while TNF-α, alone or in combination with the hormone, significantly inhibited HUVEC viability. [3H]thymidine incorporation in HUVEC treated with TNF-α or IL-1α significantly decreased, in the absence or in the presence of the hormone, while the levels of vitamin D receptor markedly increased in the presence of 1,25(OH)2D3 alone or associated with TNF-α or IL-1α, in comparison to the control. The noteworthy increase in protein levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) induced by TNF-α was significantly decreased after incubation of the cells with 1,25(OH)2D3, this effect not being seen on E-selectin expression. Neither apoptosis nor nuclear translocation of NF-κB, induced in HUVEC by TNF-α was influenced by 1,25(OH)2D3 treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 30, Issue 4, April 2006, Pages 365-375
Journal: Cell Biology International - Volume 30, Issue 4, April 2006, Pages 365-375
نویسندگان
Maria Martinesi, Sara Bruni, Maria Stio, Cristina Treves,